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KMID : 0381120120340040441
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Genes and Genomics
2012 Volume.34 No. 4 p.441 ~ p.445
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mRNA sequence analysis and quantitative expression of the ADAMTS4 gene in the thoroughbred horse
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Moon Jae-Woo
Ahn Kung
Bae Jin-Han
Nam Gyu-Hwi
Cho Byung-Wook
Park Kyung-Do
Lee Hak-Kyo
Yang Young-Mok
Kim Tae-Hun
Seong Hwan-Hoo
Han Kyu-Dong
Kim Heui-Soo
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Abstract
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Cartilage increases flexibility of motion and helps protect the body from physical shock. Strong physical shock or some biological factor could cause joint disease. ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) has been related to degradation of aggrecans in cartilage. It has been associated with joint disease, which could influence the ability of horses to exercise. Here, we performed sequence analysis and expression profiling of the ADAMTS4 gene in thoroughbred horses. Quantitative real-time RT-PCR data indicated that higher expression of the ADAMTS4 gene appeared in the cartilage tissues compared to those of pancreas, stomach, lung and colon. The expression pattern was also higher in the muscle tissues after exercise than before exercise. These data could be of great use for further studies in relation to both horse racing and joint disease.
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KEYWORD
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ADAMTS4 gene, Expression, Muscle tissues, Quantitative real-time RT-PCR, Thoroughbred horse
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